Airway epithelium and bronchial hyperresponsiveness.
نویسندگان
چکیده
منابع مشابه
Lung parenchymal shear modulus, airway wall remodeling, and bronchial hyperresponsiveness.
When airways narrow, either through the action of smooth muscle shortening or during forced expiration, the lung parenchyma is locally distorted and provides an increased peribronchial stress that resists the narrowing. Although this interdependence has been well studied, the quantitative significance of airway remodeling to interdependence has not been elucidated. We have used an improved comp...
متن کاملAirway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma.
BACKGROUND There are few data in asthma relating airway physiology, inflammation and remodelling and the relative effects of inhaled corticosteroid (ICS) treatment on these parameters. A study of the relationships between spirometric indices, airway inflammation, airway remodelling, and bronchial hyperreactivity (BHR) before and after treatment with high dose inhaled fluticasone propionate (FP ...
متن کاملSmall Airway Impairment and Bronchial Hyperresponsiveness in Asthma Onset
PURPOSE Our study tried to find a relationship between baseline FEF25-75% and airway hyperresponsiveness (AHR) and whether a greater FEF25-75% impairment may be a marker of a more severe hyperresponsiveness in subjects with normal FEV1 and FEV1/FVC and suggestive asthma symptoms. Besides, we tried to asses a FEF25-75% cut-off value to identify hyper-reactive subjects. METHODS 4,172 subjects (...
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RACHIELE et al. [1) reported on stable asthmatics in whom two histamine inhalation tests were carried out on six different days at 8, 16 and 22 h. In seven out of fifteen asthmatic subjects significant diurnal rhythms with a time range of least excitability between 9.8 and 23.1 h could be demonstrated. Diurnal changes of airway responsiveness may, therefore, be important in some patients with b...
متن کاملAllergen-induced Bronchial Hyperresponsiveness
Bradykinin (BK) is a peptide mediator generated at sites of inflammation and its effects are mediated through constitutively expressed B 2 receptor or through induction of B 1 receptors. We examined the role of these receptors in bronchial hyperresponsiveness (BHR). Brown-Norway rats sensitized with ovalbumin (OA) and Al(OH) 3 intraperitoneally, were exposed 3 wk later to either saline or OA ae...
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ژورنال
عنوان ژورنال: Ensho
سال: 1991
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.11.127